Tumor-associated macrophages enhance tumor hypoxia and aerobic glycolysis
نویسندگان
چکیده
منابع مشابه
Hypoxia and tumor-associated macrophages
Tumor-associated macrophages (TAMs) provide a significant contribution to tumor growth and metastasis. We demonstrated the existence of two main TAM subsets, differing in activation state and localization. Of these, M2-like TAMs reside in hypoxic regions of the tumor mass and can be used as targets for hypoxia tracers. This said, hypoxia does not regulate the differentiation of TAMs but finely ...
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Previous investigations from this laboratory have revealed that the over-all oxidative capacity of tumor tissues, in general, falls in the range of the less active normal tissues and at a level much lower than normal liver, kidney, heart, or brain (12), while the enzymes of the glycolytic system occur in quantities of the same order of magnitude in all these tissues (5, 6). Since the conclusion...
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The role of tumor-associated macrophages (TAMs) in cancer is often correlated with poor prognosis, even though this statement should be interpreted with care, as the effects of macrophages primarily depend on their localization within the tumor. This versatile cell type orchestrates a broad spectrum of biological functions and exerts very complex and even opposing functions on cell death, immun...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2019
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-18-2545